Webinar
Addressing the incomplete mutational landscape in pediatric cancers with Optical Genome Mapping
On-demand
In this Bionano in Motion webinar, we explore the utility and validity of an innovative strategy, proposed by Dr Brandes from Heinrich-Heine University and University Hospital Dusseldorf that combines Optical Genome Mapping (OGM) and whole exome sequencing (WES) in 60 HD and ETV6::RUNX1+ BCP-ALL cases. This study shows that OGM detected a high number of additional SVs not identified using the conventional methods, including (subclonal) IKZF1 deletions a prognostically relevant subtype.
In addition, OGM outperformed SNP-array leading to the detection of several novel recurrently altered genes. Last, the combined WES-OGM approach led to the identification of double hits of SVs and SNVs in the same individual sample demonstrating its power to define the landscape of genomic alterations in BCP-ALL.
After Dr. Brandes presents details from this study and discusses implications for the future of pediatric cancer research, Bionano’s Product Management Director, Daniel Saul, will discuss an exciting new software released by Bionano, VIA™, a complete and integrated solution for the visualization, interpretation and reporting of genomic variants, with a special pipeline to take hematological malignancy data from sample to final reported result in a seamless way!
Join us for this enlightening In Motion webinar and stay for an engaging and interactive Q&A session at the end, with our expert presenters.
Danielle Brandes
Danielle Brandes is a PhD student at the Heinrich-Heine University Düsseldorf and associated graduate student of the Düsseldorf School of Oncology.
She joined the Pediatric Oncology Department of the University Clinics Düsseldorf in 2020 and started her research project under the supervision of Prof. Dr. Arndt Borkhardt. Since then, she is interested in genomic variation with regard to childhood cancer predisposition and pathogenesis, with focus on B-cell precursor acute lymphoblastic leukemia. She aims to decipher structural variation landscapes of children with cancer by applying optical genome mapping and long-read sequencing approaches.
Danielle completed her Bachelor of Science in Biology at the Johannes Gutenberg University Mainz followed by a Master of Science in Molecular Biomedicine at the University of Münster.
Daniel Saul
Daniel Saul is a director of product management software and informatics, at Bionano.
Prior to joining Bionano, he had held several roles at Illumina, including product manager of cytogenomic solutions, and had previously worked in Cytogenetics laboratories at the Johns Hopkins University and GeneDx.
Daniel obtained a MS in Biotechnology from the Johns Hopkins University and a M.B.A. from the University of Maryland University College.